A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name CD9 siRNA
ncRNA Category siRNA
Disease name choroidal neovascularization (CNV)
Species Homo sapiens
Tissues/Cell_line normal adult human dermal microvascular endothelial cells (HMVECs)
Methods siRNA transfection, WST-8 assay, immunocytochemistry, TUNEL assay, immunoblot, siRNA injection
Expression pattern associated
Functional description Injecting CD9-specific small interfering RNA (siRNA-CD9) markedly inhibited HGF- or VEGF-induced subconjunctival angiogenesis in vivo. Furthermore, intravitreous injections of siRNA-CD9 or anti-CD9 antibodies were therapeutically effective for laser-induced retinal and choroidal neovascularization in mice, a representative ocular angiogenic disease model.
PubMed ID 21875571
Year 2011
Title Targeting CD9 produces stimulus-independent antiangiogenic effects predominantly in activated endothelial cells during angiogenesis: a novel antiangiogenic therapy.
Drug-related ncRNA NO

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