A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name hsa-miR-29
ncRNA Category miRNA
Disease name choroidal neovascularization (CNV)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19; umbilical vein endothelial cell line EA hy926; human embryonic kidney cell line HEK293
Methods immunohistochemistry, transfection, Western blot, qRT-PCR, luciferase reporter assay
Expression pattern down-regulated
Functional description NFκB activation inhibits miR-29s, which may contribute to angiogenesis by up-regulating the MMP-2 protein level in RPE cells.
PubMed ID 24886609
Year 2014
Title Roles of NFκB-miR-29s-MMP-2 circuitry in experimental choroidal neovascularization.
Drug-related ncRNA NO

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