A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name Dll4 siRNA
ncRNA Category siRNA
Disease name choroidal neovascularization (CNV)
Species Macaca mulatta
Tissues/Cell_line rhesus choroid-retinal endothelial cell line RF/6A
Methods RT-PCR, qPCR, Western blot, siRNA transfection, flow cytometry, MTT assay, transwell assay, tube formation assay
Expression pattern associated
Functional description Knockdown of DLL4 expression significantly promoted the proliferation of hypoxic RF/6A cells and led to their arrest in the S phase of the cell cycle. Migration and tube formation of hypoxic RF/6A cells were significantly induced by the DLL4 siRNA, with the number of migrated cells increased by 1.6-fold and total tube length increased by 82.3%, compared with the scrambled siRNA.
PubMed ID 21362319
Year 2011
Title Effect of DLL4 siRNA on proliferation, migration and tube formation of choroid-retinal endothelial cells under hypoxic conditions.
Drug-related ncRNA NO

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