|choroidal neovascularization (CNV)
|RPE cells, choroidal microvascular endothelial cells (CECs)
|immunohistochemistry, Western blot, siRNA transfection, semi-qRT-PCR, ELISA
|The absence of FAK effectively reduced the expression of hypoxia-induced HIF-1alpha and VEGF in RPE cells, resulting in the inhibition of proliferation and migration of choroidal microvascular endothelial cells (CECs).
|Focal adhesion kinase signaling pathway participates in the formation of choroidal neovascularization and regulates the proliferation and migration of choroidal microvascular endothelial cells by acting through HIF-1 and VEGF expression in RPE cells.
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