A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name p22phox-siRNA
ncRNA Category siRNA
Disease name choroidal neovascularization (CNV)
Species Mus musculus
Tissues/Cell_line retinas and RPE/choroids
Methods Western blot, immunofluorescent localization, in situ hybridization, siRNA injection, ELISA
Expression pattern associated
Functional description A small-interfering RNA (siRNA) designed against p22phox efficiently reduced the expression of the protein in the eye when delivered by means of recombinant adeno-associated virus (AAV) vector. Vector treatment inhibited CNV in the mouse when delivered into the subretinal space where RPE cells were transduced.
PubMed ID 18665154
Year 2008
Title Downregulation of p22phox in retinal pigment epithelial cells inhibits choroidal neovascularization in mice.
Drug-related ncRNA NO

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