A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name factor B siRNA
ncRNA Category siRNA
Disease name choroidal neovascularization (CNV)
Species Mus musculus
Tissues/Cell_line RPE-choroid-scleral tissues, serum
Methods siRNA injection, immunohistochemistry, RT-PCR, Western blot
Expression pattern associated
Functional description Inhibition of the alternative pathway by factor B siRNA resulted in decreased levels of membrane attack complex and angiogenic factors-vascular endothelial growth factor and TGF-beta2.
PubMed ID 16849499
Year 2006
Title Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H.
Drug-related ncRNA NO

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