|choroidal neovascularization (CNV)
|human aortic endothelial cells (HAECs), HeLa S3 cells
|BrdU labeling, siRNA transfection, qRT-PCR, luciferase reporter assay, ELISA
|We used siRNA directed against vegfr1 mRNA to investigate the role of VEGFR1 in ocular neovascularization. After evaluating many siRNAs, Sirna-027 was identified. In a CNV model, intravitreous or periocular injections of Sirna-027 resulted in significant reductions in the area of NV. In mice with ischemic retinopathy, intravitreous injection of Sirna-027 reduced retinal NV by 32%.
|Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1.
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