|choroidal neovascularization (CNV)
|human embryonic kidney cell line HEK293, HeLa cells
|siRNA transfection, ELISA
|SiRNAs directed against hVEGF effectively and specifically inhibit hypoxia-induced VEGF levels in human cell lines and after adenoviral induced hVEGF transgene expression in vivo. In addition, subretinal delivery of siRNA directed against murine Vegf significantly inhibited CNV after laser photocoagulation.
|Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model.
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