|choroidal neovascularization (CNV)
|human umbilical vein endothelial cells (HUVECs)
|transfection, qRT-PCR, Northern blot, Western blot, luciferase reporter assay
|miR-24 has been shown to regulate apoptosis and inhibit cell proliferation. In the absence of miR-23 and miR-27, there is a compensatory up-regulation of miR-24 in our in vitro and in vivo knockdown assays. The potential role of miR-24 in angiogenesis awaits future studies.
|Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters.
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