A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name hsa-miR-23b
ncRNA Category miRNA
Disease name choroidal neovascularization (CNV)
Species Homo sapiens
Tissues/Cell_line human umbilical vein endothelial cells (HUVECs)
Methods transfection, qRT-PCR, Northern blot, Western blot, luciferase reporter assay
Expression pattern up-regulated
Functional description miR-23 and miR-27 enhance angiogenesis by promoting angiogenic signaling through targeting Sprouty2 and Sema6A proteins, which exert antiangiogenic activity.
PubMed ID 21536891
Year 2011
Title Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters.
Drug-related ncRNA NO

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