A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name mmu-miR-21
ncRNA Category miRNA
Disease name choroidal neovascularization (CNV)
Species Mus musculus
Tissues/Cell_line choroids
Methods Taqman assay, transfection, Boyden chamber migration assay, scratch wound assay, BrdU incorporation assay, qRT-PCR, Western blot, luciferase reporter assay, isolectin-B4 staining
Expression pattern down-regulated
Functional description Our results identify miR-21 as a new angiogenesis inhibitor and suggest that inhibition of cell migration and tubulogenesis is mediated through repression of RhoB. The therapeutic potential of miR-21 as an angiogenesis inhibitor was demonstrated in vivo in a mouse model of choroidal neovascularization.
PubMed ID 21347332
Year 2011
Title MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells.
Drug-related ncRNA NO

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