A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name p75NTR shRNA
ncRNA Category shRNA
Disease name choroidal neovascularization (CNV)
Species Rattus norvegicus
Tissues/Cell_line brain microvascular endothelial cells (RBMVEC)
Methods shRNA knockdown, Western Blot
Expression pattern associated
Functional description LMPs markedly inhibit choroidal angiogenesis via mechanisms that are dependent on the integrity of the RPE, and that are mediated largely by the PEDF and proapoptotic activities of p75NTR. Downregulation of PEDF and p75NTR significantly blocked the antiangiogenic effects of LMPs.
PubMed ID 23920372
Year 2013
Title p75 neurotrophin receptor participates in the choroidal antiangiogenic and apoptotic effects of T-lymphocyte-derived microparticles.
Drug-related ncRNA NA

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