|choroidal neovascularization (CNV)
|brain microvascular endothelial cells (RBMVEC)
|shRNA knockdown, Western Blot
|LMPs markedly inhibit choroidal angiogenesis via mechanisms that are dependent on the integrity of the RPE, and that are mediated largely by the PEDF and proapoptotic activities of p75NTR. Downregulation of PEDF and p75NTR significantly blocked the antiangiogenic effects of LMPs.
|p75 neurotrophin receptor participates in the choroidal antiangiogenic and apoptotic effects of T-lymphocyte-derived microparticles.
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