|choroidal neovascularization (CNV)
|retinas and choroids
|shRNA knockdown, IB4 or H&E staining, fluorescein angiography, qPCR, Western blot
|Treatment with PDGF-CC shRNA, which reduced the PDGF-CC expression level to approximately 40% of normal level, reduced CNV area 7 d after laser treatment when injected into vitreous or subretinal space.
|PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets.
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