A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name PDGF-CC shRNA
ncRNA Category shRNA
Disease name choroidal neovascularization (CNV)
Species Mus musculus
Tissues/Cell_line retinas and choroids
Methods shRNA knockdown, IB4 or H&E staining, fluorescein angiography, qPCR, Western blot
Expression pattern associated
Functional description Treatment with PDGF-CC shRNA, which reduced the PDGF-CC expression level to approximately 40% of normal level, reduced CNV area 7 d after laser treatment when injected into vitreous or subretinal space.
PubMed ID 20566880
Year 2010
Title PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets.
Drug-related ncRNA NA

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