A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name VEGF shRNA
ncRNA Category shRNA
Disease name choroidal neovascularization (CNV)
Species Mus musculus
Tissues/Cell_line mouse eyes
Methods shRNA knockdown, fluorescence microscopy, histology and lectin staining, fluorescein angiography
Expression pattern associated
Functional description shRNA targeting VEGF from adenovirus vectors allows potent attenuation of VEGF and prevents CNV.
PubMed ID 16877421
Year 2006
Title Inhibition of choroidal neovascularization by adenovirus-mediated delivery of short hairpin RNAs targeting VEGF as a potential therapy for AMD.
Drug-related ncRNA NA

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