|choroidal neovascularization (CNV)
|human RPE cells
|shRNA knockdown, qRT-PCR, Western blot, MTT assay, migration assay, tube formation assay
|RNAi of HIF-1alpha in RPE cells can inhibit angiogenesis in vitro and provide a possible strategy for treatment of choroidal neovascularization diseases by targeting HIF-1alpha.
|Inhibition of proliferation, migration and tube formation of choroidal microvascular endothelial cells by targeting HIF-1alpha with short hairpin RNA-expressing plasmid DNA in human RPE cells in a coculture system.
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