| ncRNA name | HIF-1α shRNA |
| ncRNA Category | shRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cells |
| Methods | shRNA knockdown, qRT-PCR, Western blot, MTT assay, migration assay, tube formation assay |
| Expression pattern | associated |
| Functional description | RNAi of HIF-1alpha in RPE cells can inhibit angiogenesis in vitro and provide a possible strategy for treatment of choroidal neovascularization diseases by targeting HIF-1alpha. |
| PubMed ID | 18523795 |
| Year | 2008 |
| Title | Inhibition of proliferation, migration and tube formation of choroidal microvascular endothelial cells by targeting HIF-1alpha with short hairpin RNA-expressing plasmid DNA in human RPE cells in a coculture system. |
| Drug-related ncRNA | NA |
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