A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name ILK siRNA
ncRNA Category siRNA
Disease name choroidal neovascularization (CNV)
Species Rattus norvegicus
Tissues/Cell_line RPE-choroid-sclera complexes
Methods siRNA injection, immunohistochemistry, immunofluorescence staining, FFA, qPCR, RT-PCR
Expression pattern associated
Functional description We found that hypoxia strongly induced the expression of ILK, HIF-1α, SDF-1, and VEGF. Moreover, the silencing of ILK attenuated their expression. It also decreased the phosphorylation of protein kinase B (PKB/AKT) and extracellular regulated protein kinases (ERK) and nearly abolished the proliferation, migration, and adhesion of EPC to RPE cells.
PubMed ID 29610861
Year 2018
Title Integrin-Linked Kinase Controls Choroidal Neovascularization by Recruitment of Endothelial Progenitor Cells.
Drug-related ncRNA NO

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