A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name YAP siRNA
ncRNA Category siRNA
Disease name choroidal neovascularization (CNV)
Species Mus musculus
Tissues/Cell_line RPE-choroid-sclera complexes and retinas
Methods Western blot, immunohistochemistry, siRNA injection, fundus fluorescein angiography, H&E staining, immunofluorescent double staining
Expression pattern associated
Functional description YAP siRNA and ranibizumab decreased VEGF expression and the incidence and leakage area of CNV. After laser exposure, YAP siRNA inhibited the increased expression of PCNA, which was colocalized with endothelial cells.
PubMed ID 29422766
Year 2018
Title Inhibition of YAP ameliorates choroidal neovascularization via inhibiting endothelial cell proliferation.
Drug-related ncRNA NO

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