|choroidal neovascularization (CNV)
|RPE-choroid-sclera complexes and retinas
|Western blot, immunohistochemistry, siRNA injection, fundus fluorescein angiography, H&E staining, immunofluorescent double staining
|YAP siRNA and ranibizumab decreased VEGF expression and the incidence and leakage area of CNV. After laser exposure, YAP siRNA inhibited the increased expression of PCNA, which was colocalized with endothelial cells.
|Inhibition of YAP ameliorates choroidal neovascularization via inhibiting endothelial cell proliferation.
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