|choroidal neovascularization (CNV)
|human RPE cell line ARPE-19; human umbilical vein endothelial cells (HUVECs)
|FFA, H&E staining, immunofluorescence, siRNA transfection, Western blot, immunoprecipitation, ELISA, qPCR
|Silencing CYLD by siRNA remarkably blocked OX-LDL-induced VEGF secretion compared with the control. Tube formation experiment also proved that silencing CYLD mRNA decreased the tube length of HUVECs after OX-LDL stimulation.
|Salvianolic Acid A Inhibits OX-LDL Effects on Exacerbating Choroidal Neovascularization via Downregulating CYLD.
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