A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name CYLD siRNA
ncRNA Category siRNA
Disease name choroidal neovascularization (CNV)
Species Mus musculus
Tissues/Cell_line human RPE cell line ARPE-19; human umbilical vein endothelial cells (HUVECs)
Methods FFA, H&E staining, immunofluorescence, siRNA transfection, Western blot, immunoprecipitation, ELISA, qPCR
Expression pattern associated
Functional description Silencing CYLD by siRNA remarkably blocked OX-LDL-induced VEGF secretion compared with the control. Tube formation experiment also proved that silencing CYLD mRNA decreased the tube length of HUVECs after OX-LDL stimulation.
PubMed ID 29081889
Year 2017
Title Salvianolic Acid A Inhibits OX-LDL Effects on Exacerbating Choroidal Neovascularization via Downregulating CYLD.
Drug-related ncRNA NO

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