A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of cataract
ncRNA name hsa-miR-181a
ncRNA Category miRNA
Disease name cataract
Species Homo sapiens
Tissues/Cell_line human lens epithelial cell line HLE-B3
Methods RNAi, flow cytometry, qRT-PCR, ELISA
Expression pattern associated
Functional description miR-181a knockdown may protect HLE‑B3 cells against H2O2‑induced apoptosis in vitro. The molecular mechanisms involved in the protective effects of miR‑181a silencing may involve the suppression of CASP3, BAX and COX‑2 expression, and the inhibition of MDA generation.
PubMed ID 29484431
Year 2018
Title Downregulation of microRNA-181a attenuates hydrogen peroxide-induced human lens epithelial cell apoptosis in vitro.
Drug-related ncRNA NO

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