A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of cataract
ncRNA name ANRIL
ncRNA Category lncRNA
ID 100048912
Ensembl ENSG00000240498
Synonyms CDKN2B-AS1, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, RP11-145E5.4, p15AS
Disease name cataract
Species Homo sapiens
Tissues/Cell_line human lens epithelial cell line SRA01/04
Methods shRNA knockdown, cytotoxicity assay, apoptosis assay, qRT-PCR, Western blot
Expression pattern up-regulated
Functional description Tanshinone IIA protects SRA01/04 cells from apoptosis triggered by H2O2. The expression of lncRNA ANRIL was upregulated by Tanshinone IIA. And, the protective effects of Tanshinone IIA on H 2 O 2 -stimulated SRA01/04 cells were abolished when lncRNA ANRIL was silenced.
PubMed ID 30701534
Year 2019
Title Tanshinone IIA protects lens epithelial cells from H2 O 2 -induced injury by upregulation of lncRNA ANRIL.
Drug-related ncRNA YES (Tanshinone IIA)

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.