A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of autoimmune uveitis
ncRNA name rno-miR-146a
ncRNA Category miRNA
Disease name autoimmune uveitis
Species Rattus norvegicus
Tissues/Cell_line iris and ciliary bodies
Methods immunofluorescence staining, Western blotting, NF-κB Electrophoretic Mobility Shift assay
Expression pattern associated
Functional description miR-146a is considered a promising candidate for the treatment of uveitis. First, the effect of miR-146a treatment in disease amelioration was well shown in clinical scores, leukocyte infiltration in the aqueous humor, and histologic findings. Second, miR-146a treatment suppressed multiple proinflammatory cytokines, such as IL-1β, IL-6, IL-12p35, and IFN-γ. Third, the results of immunofluorescence, Western blotting, and EMSA revealed that miR-146a regulated the disease process in an NF-κB-dependent manner.
PubMed ID 29434444
Year 2017
Title MicroRNA-146a Alleviates Experimental Autoimmune Anterior Uveitis in the Eyes of Lewis Rats
Drug-related ncRNA NO

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