|flow cytometry, ELISA, microarray, qRT-PCR, siRNA transfection
|Our data support the hypothesis that RPE cells produce RA, thereby enabling bystander T cells to be converted into Tregs through TGFβ promotion, which can then participate in the establishment of immune tolerance in the eye. RA receptor antagonist-pretreated or RA-binding protein-siRNA-transfected RPE cells failed to convert CD4(+) T cells into Tregs.
|Retinoic acid from retinal pigment epithelium induces T regulatory cells.
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