A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of age-related cataract
ncRNA name hsa-miR-24
ncRNA Category miRNA
Disease name age-related cataract
Species Homo sapiens
Tissues/Cell_line anterior lens capsules; human lens epithelial cell line SRA01/04
Methods qRT-PCR, Western blot, cell viability assay, Caspase-3 activity assay, transfection, luciferase reporter assay
Expression pattern up-regulated
Functional description miR-24 evoked by oxidative stress enhances LEC apoptosis and inhibits LEC proliferation by directly targeting p53, also contributing to the development of cataracts.The p53 signaling pathway plays an important role in regulating the cell cycle and cell differentiation, promoting apoptosis, and activating cell death.
PubMed ID 29393409
Year 2018
Title miR-24-p53 pathway evoked by oxidative stress promotes lens epithelial cell apoptosis in age-related cataracts.
Drug-related ncRNA NO

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