A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of age-related cataract
ncRNA name hsa-miR-34a
ncRNA Category miRNA
Disease name age-related cataract
Species Homo sapiens
Tissues/Cell_line lens epithelium samples; SRA01/04
Methods qRT-PCR, transfection, flow cytometry, luciferase reporter assay
Expression pattern up-regulated
Functional description MicroRNA-34a is increased in the cataractous lens and triggers mitochondria-mediated apoptosis and oxidative stress by suppressing Notch2.
PubMed ID 29299142
Year 2017
Title MicroRNA-34a promotes mitochondrial dysfunction-induced apoptosis in human lens epithelial cells by targeting Notch2.
Drug-related ncRNA NO

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