A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of age-related cataract
ncRNA name hsa-miR-21-3p
ncRNA Category miRNA
Disease name age-related cataract
Species Homo sapiens
Tissues/Cell_line capsule samples; human embryonic kidney cell line HEK293T; human hepatoblastoma cell line HepG2
Methods Comet assay, qPCR, luciferase reporter assay
Expression pattern associated
Functional description The association of SNP rs2278414 with ARC might involve an altered miRNA regulation of ZNF350. The in vitro experiment indicated that miR-21-3p and miR-150-5p specifically downregulated luciferase reporter expression in the cell lines transfected with rs2278414 A allele compared with rs2278414 G.
PubMed ID 27586871
Year 2016
Title Functional SNP in 3'-UTR MicroRNA-Binding Site of ZNF350 Confers Risk for Age-Related Cataract.
Drug-related ncRNA NO

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