A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of acanthamoeba keratitis
ncRNA name SP siRNA
ncRNA Category siRNA
Disease name acanthamoeba keratitis
Species Rattus norvegicus
Tissues/Cell_line corneas
Methods siRNA transfection, histological analysis
Expression pattern associated
Functional description A murine model of ocular keratitis was treated with siGP + siSP-loaded liposomes, as well as their respective controls, and combined treatment of liposomes and chlorhexidine. After 15 days of eight daily administrations, the liposomal complex combined with chlorhexidine was the only treatment able to reverse the more severe lesions associated with keratitis.
PubMed ID 30384269
Year 2019
Title Box Behnken design of siRNA-loaded liposomes for the treatment of a murine model of ocular keratitis caused by Acanthamoeba.
Drug-related ncRNA NO

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