A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of Pseudomonas aeruginosa keratitis
ncRNA Category siRNA
Disease name Pseudomonas aeruginosa keratitis
Species Mus musculus
Tissues/Cell_line corneas
Methods siRNA injection, qPCR, cytokines assay, Western blot
Expression pattern associated
Functional description EMMPRIN promotes host resistance against pseudomonas aeruginosa infection via MAPK signaling pathway. Silence of EMMPRIN Enhanced the Production of pro-inflammatory cytokines in PA keratitis. Silence of EMMPRIN significantly up-regulated Th1-type cytokines IFN-γ, IL-12, and IL-18, but down-regulated Th2-type cytokines IL-4, IL-5, and IL-10.
PubMed ID 28078032
Year 2016
Title Extracellular matrix metalloproteinase inducer enhances host resistance against pseudomonas aeruginosa infection through MAPK signaling pathway.
Drug-related ncRNA NO

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