ncRNA name | HIF-1α siRNA |
ncRNA Category | siRNA |
Disease name | Pseudomonas aeruginosa keratitis |
Species | Mus musculus |
Tissues/Cell_line | corneas |
Methods | siRNA injection, qRT-PCR, immunofluorescent staining, ELISA |
Expression pattern | associated |
Functional description | Inhibition of HIF-1α converts a normally resistant disease response to susceptible (corneal thinning and perforation) after induction of bacterial keratitis. |
PubMed ID | 23874197 |
Year | 2013 |
Title | HIF-1α is essential for effective PMN bacterial killing, antimicrobial peptide production and apoptosis in Pseudomonas aeruginosa keratitis. |
Drug-related ncRNA | NO |
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