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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of Pseudomonas aeruginosa keratitis
ncRNA name HIF-1α siRNA
ncRNA Category siRNA
Disease name Pseudomonas aeruginosa keratitis
Species Mus musculus
Tissues/Cell_line corneas
Methods siRNA injection, qRT-PCR, immunofluorescent staining, ELISA
Expression pattern associated
Functional description Inhibition of HIF-1α converts a normally resistant disease response to susceptible (corneal thinning and perforation) after induction of bacterial keratitis.
PubMed ID 23874197
Year 2013
Title HIF-1α is essential for effective PMN bacterial killing, antimicrobial peptide production and apoptosis in Pseudomonas aeruginosa keratitis.
Drug-related ncRNA NO

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