A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of Pseudomonas aeruginosa keratitis
ncRNA name TREM-2 siRNA
ncRNA Category siRNA
Disease name Pseudomonas aeruginosa keratitis
Species Mus musculus
Tissues/Cell_line corneas; murine macrophage-like RAW264.7 cells
Methods siRNA transfection and injection, qPCR, Western blot, H&E staining, flow cytometry, ELISA
Expression pattern associated
Functional description Silencing of TREM-2 accelerated disease progression by enhancing bacterial load and corneal inflammation.
PubMed ID 23611998
Year 2013
Title TREM-2 promotes host resistance against Pseudomonas aeruginosa infection by suppressing corneal inflammation via a PI3K/Akt signaling pathway.
Drug-related ncRNA NO

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