ncRNA name | MRP8/14 siRNA |
ncRNA Category | siRNA |
Disease name | Pseudomonas aeruginosa keratitis |
Species | Mus musculus |
Tissues/Cell_line | corneas; murine macrophage-like RAW264.7 cells |
Methods | siRNA transfection and injection, qPCR, Western blot, immunohistochemistry, ELISA, flow cytometry |
Expression pattern | associated |
Functional description | Silencing of MRP8/14 in B6 corneas significantly reduced the severity of corneal disease, bacterial clearance, PMN infiltration, and pro-inflammatory cytokine expression after PA infection. In vitro studies demonstrated further that silencing of MRP8/14 suppressed pro-inflammatory cytokine production, bacterial killing, and ROS production, but not phagocytosis or NO production. |
PubMed ID | 23299480 |
Year | 2013 |
Title | MRP8/14 enhances corneal susceptibility to Pseudomonas aeruginosa Infection by amplifying inflammatory responses. |
Drug-related ncRNA | NO |
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