A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of Pseudomonas aeruginosa keratitis
ncRNA name MRP8/14 siRNA
ncRNA Category siRNA
Disease name Pseudomonas aeruginosa keratitis
Species Homo sapiens
Tissues/Cell_line human monocytic THP-1 cells
Methods siRNA transfection, qPCR, Western blot, immunohistochemistry, ELISA, flow cytometry
Expression pattern associated
Functional description Silencing of MRP8/14 in B6 corneas significantly reduced the severity of corneal disease, bacterial clearance, PMN infiltration, and pro-inflammatory cytokine expression after PA infection. In vitro studies demonstrated further that silencing of MRP8/14 suppressed pro-inflammatory cytokine production, bacterial killing, and ROS production, but not phagocytosis or NO production.
PubMed ID 23299480
Year 2013
Title MRP8/14 enhances corneal susceptibility to Pseudomonas aeruginosa Infection by amplifying inflammatory responses.
Drug-related ncRNA NO

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