A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of Pseudomonas aeruginosa keratitis
ncRNA name TLR9 siRNA
ncRNA Category siRNA
Disease name Pseudomonas aeruginosa keratitis
Species Mus musculus
Tissues/Cell_line corneas; mouse Langerhans cell line XS52
Methods qRT-PCR, siRNA transfection and injection, ELISA, immunostaining
Expression pattern associated
Functional description LCs stimulated with CpG DNA and treated with TLR9 siRNA exhibited reduced TLR9, IL-1beta, and MIP-2 levels compared with controls. Finally, B6 mice treated with TLR9 siRNA showed decreases in corneal opacity, polymorphonuclear leukocyte number, IL-12 and IFN-gamma mRNA, IL-1beta, and MIP-2 protein compared with those treated with control siRNA.
PubMed ID 16249500
Year 2005
Title Silencing Toll-like receptor-9 in Pseudomonas aeruginosa keratitis.
Drug-related ncRNA NO

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