A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of Pseudomonas aeruginosa keratitis
ncRNA name TSLPR siRNA
ncRNA Category siRNA
Disease name Pseudomonas aeruginosa keratitis
Species Mus musculus
Tissues/Cell_line corneas
Methods siRNA injection, ELISA, qPCR, Western blot
Expression pattern associated
Functional description Targeting TSLP or TSLPR with neutralizing antibodies or TSLPR with siRNA resulted in more severe keratitis, attributable to an increase in bacterial burden and PMN infiltration.
PubMed ID 30128494
Year 2018
Title TSLP Protects Corneas From Pseudomonas aeruginosa Infection by Regulating Dendritic Cells and IL-23-IL-17 Pathway.
Drug-related ncRNA NO

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