A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of Pseudomonas aeruginosa keratitis
ncRNA name NLRC4 siRNA
ncRNA Category siRNA
Disease name Pseudomonas aeruginosa keratitis
Species Mus musculus
Tissues/Cell_line corneas
Methods siRNA injection, ELISA, Western blot, flow cytometric, caspase-1 detection
Expression pattern associated
Functional description Flow cytometry to identify cells affected by silencing, showed reduced caspase-1 levels in a CD11blowLy6Glow population of cells, (but not PMN or macrophages) from the infected cornea of siNLRC4 treated mice that produced less mature IL-1beta.
PubMed ID 28961278
Year 2017
Title NLRC4 regulates caspase-1 and IL-1beta production in a CD11blowLy6Glow population of cells required for resistance to Pseudomonas aeruginosa keratitis.
Drug-related ncRNA NO

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.