A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of Fusarium solani keratitis
ncRNA name Dectin-1 siRNA
ncRNA Category siRNA
Disease name Fusarium solani keratitis
Species Homo sapiens
Tissues/Cell_line human corneal epithelial cells (HCECs)
Methods siRNA transfection, qRT-PCR, immunoblot, flow cytometry
Expression pattern associated
Functional description HCECs express Dectin-1 and TLR2. HCECs demonstrated upregulation of AMPs hBD2 and cathelicidin LL37 following exposure to heat-inactivated F. solani or PAMPs. TLR2 and Dectin-1 knockdown and BAY 61-3606 treatment decreased AMP mRNA upregulation confirming PRR involvement.
PubMed ID 28460048
Year 2017
Title Role of Pattern Recognition Receptors in the Modulation of Antimicrobial Peptide Expression in the Corneal Epithelial Innate Response to F. solani.
Drug-related ncRNA NO

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